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Taken together, preclinical works have supported the role of imbalances in the accumbal glutamatergic system as a driver of addictive behaviors in rodents

We selected the G12D and G12V mutations because of their high frequency across all KRAS-driven cancers (including colorectal cancer) (Figure S1A), G12C for its high prevalence only in lung adenocarcinoma, and G12A because it is infrequently observed in colorectal adenocarcinoma yet biochemically indistinguishable from G12V 7

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10.1046/j.1432-1327.1999.00625.x 67 PravalikaK.SarmahD.KaurH.VatsK.SarafJ.WanveM.et al (2018)