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Keywords: Glucagon, Glucagon-like peptide-1 receptor agonist, Glucose-dependent insulinotropic peptide receptor, Incretin, Obesity, Type 2 diabetes mellitus Introduction Type 2 diabetes mellitus (T2DM) and obesity are becoming more and more common worldwide, a phenomenon which greatly increases morbidity and mortality from conditions like cancer and heart disease, among many others [1]

Experimental observations include reduced severity of hemorrhagic events, improved cardiac rhythm stability, and attenuation of injury in organs such as the lungs, liver, kidneys, and gastrointestinal tract.(24) These outcomes appear to be linked to preservation of vascular integrity and improved microcirculatory function, underscoring its broad organ-supportive activity within preclinical research settings

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