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Description

In vitro study demonstrated that SIRT1 attenuates degeneration of DNs by increasing expression of FOXO3a and hypoxia-inducible factor 1 alpha (HIF-1) with inhibition of oxidative stress (Rodriguez et al

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Specifically, FOXO activity is essential for the execution of apoptosis under stress conditions (Tomohiro and Sakamoto, 2008)

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It acts as a signaling molecule in the body

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