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Furthermore, prolonged treatment with 5-AZA and DAC (48 h) has a more significant impact on DNMT1 depletion, the induction of DNA damage, and the upregulation of gene expression [153]

[ CrossRef ] [ Google scholar ] Bobyntsev II, Chernysheva OI, Dolgintsev ME, Smakhtin MY, Belykh AE

The slow titration schedule described in the dosing section is specifically designed to minimize these effects

5 Limitations and future directions of research Given the scope of the present study, several key factors warrant acknowledgment: First, bridging the translational gap between animal models and human clinical applications is challenging