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Various mechanisms are involved in the pharmacological action of baxiaga

Irradiated sperm may modify the arrangement of microtubules and interrupt the work of mitochondria (44), which can damage the function and morphology of germ cells and even cause serious damage to DNA in germ cells, resulting in defective DNA

Considering that reduced DNA-methylation can be one of the consequences of B12-deficiency (see Section 2.4), these data provide a mechanistic explanation of how B12-deficiency may be involved in the pathogenesis of DPN