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Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 (Guo et al., 2016), and esculentoside A that activates Nrf2 via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)

Because GAC is generally used to treat many common groundwater contaminants, it is capable of also treating most organic co-contaminants that may be present, with the primary impact being increased GAC consumption due to greater loading per unit of time, which may require more frequent change-outs

For example, GABAergic interneurons (e.g., parvalbumin-positive neurons) possess different redox dynamics and delayed antioxidant system maturation, making them particularly vulnerable to oxidative stress during critical developmental windows [94, 95]

doi: 10.1016/j.foodres.2022.112382 90 LiZ.-R.WangB.ChiC.-f.ZhangQ.-H.GongY.-d.TangJ.-J.et al