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Although it has been shown that bilirubin is mainly inhibitory in its effect on the proliferation of tumors, it can also exhibit promotional properties in some aspects, and further studies on its inhibitory properties will help to generate new therapies for tumors, while studies on its promotional properties can give us a better knowledge of the two-faced nature of bilirubin, which can be used to aid in the side-by-side development of new treatments for tumors