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For more severe acne, isotretinoin is an option: Isotretinoin (Accutane) is an oral retinoid for severe, cystic acne unresponsive to other treatments

(2019) 179:93752.e18

They release (ROS) and proteolytic enzymes within the phagosome in a process termed the Respiratory Burst

There is a paucity of literature that explores how the disruption of intestinal barrier functions resulting from these conditions and/or their treatment impacts the disease phenotypes and complications experienced by the patients