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Acknowledgments The authors thank the Department of Orthopedic Surgery for the academic and administrative support

LKB1 regulates mitochondria-dependent presynaptic calcium clearance and neurotransmitter release properties at excitatory synapses along cortical axons

Up to 4050% of patients with ALS demonstrate mild-to-moderate cognitive impairment, primarily involving executive dysfunction and impaired verbal fluency, with 15% of patients meeting criteria for frontotemporal dementia (FTD) [2]