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The sensitization potential of CB-839 on cells treated with venetoclax ( Figures 6AC ), AZD-5991 ( Figures 6DF ), or ibrutinib ( Figures 6GI ) was assessed using the Loewe additivity model and validated using annexin V/PI staining

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The methylation levels of LAD1 (154,269) and NEFH (270) can also reflect the outcome of drug treatment of renal cell carcinoma to a certain extent, helping physicians to adjust the treatment plan in time