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High activity of NNMT is also correlated with lower levels of glucose transporter 4 (GLUT4), which is vital for glucose uptake from the bloodstream into fat and muscle cells

These adverse outcomes are seen, on average, after days to weeks of treatment, although oligohydramnios has been infrequently reported as soon as 48 hours after NSAID initiation

14 Establish the first commercial laboratory (1985) for measuring normal levels of MMA using gas chromatography mass spectrometry making the assay an available clinical test