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Orlich MJ, Siapco G, Jung S, et al

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14 Updated guidelines released by the Infectious Diseases Society of America (IDSA) in 2010 can assist health care professionals in the management of women with uncomplicated UTIs

Using mouse embryonic fibroblasts (MEFs) and human malignant melanoma cells treated with active-site mTOR inhibitor (asTORi), was demonstrate that mTORC1 stimulates the translation of MTFP1 mediated by 4E-BP, and therefore the mTOR inhibition induces the phosphorylation of the DRP1 at Ser 637, this phosphorylation prevents it translocation to mitochondria, conversely, the pro-fission phosphorylation site of DRP1 at Ser 616 was decreased in asTORi treated cells