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EPA in particular has demonstrated antidepressant-like effects in clinical trials, with a 2019 meta-analysis in Translational Psychiatry finding significant mood benefits from EPA-dominant supplementation

The discrepancy may reflect differences in concentration, exposure time, assay method, culture conditions, or peptide-batch characteristics, but it has not yet been resolved experimentally

Acknowledgments This research article is a result of the collaboration between Ain Shams University, Yogi Vemana University Kadapa, Qassim University, and University Malaysia Kelantan

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