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Although FDA approval is granted for alternative applications, their stance on skin whitening efficacy remains neutral

53 Although they have been classified as endocrine disruptors (binding to ER at lower levels compared to 17-estradiol), this is a very narrow view, and these compounds are coming to the forefront as agonist-antagonist SERMs that are especially suited for MHT

These promising findings offer a paradigm shift in actively targeted ferroptosis therapies and present AAP NPs as a potential for clinical translation in COC treatment

However, there appears to be heterogeneity in reactions to co-supplementing vitamin E and selenium