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10.1016/j.bbagen.2012.11.019 Biochim

KO hearts also especially developed left ventricular hypertrophy and fibrosis, yet cardiac contraction and relaxation remained the same between wildtype and KO mice [39, 42]

Oxidative stress is implicated in the pathogenesis of SLE through multiple mechanisms, including mitochondrial dysfunction, activation of the type I IFN pathway, and the generation of oxidative DNA damage [130]