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While symptoms of peripheral neuropathy vary, some of the more common symptoms include, but are not limited to: Burning Tingling Pins and needles sensation Cold toes Numbness Tightness Feeling of wearing a stocking or sock around your feet, ankles, legs Swelling Feeling of a rubber band around the feet, ankles, or legs Balance problems What causes peripheral neuropathy

Around 1520% of patients with IBD demonstrate hypermethylation when treated with thiopurines, resulting in preferential metabolism of MP to methylmercaptopurine (MeMP)[54]

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The long-term picture in people is essentially unknown