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Blood (2009) 113(15):35425

Following a gradual overload running training (5 days/week, 5 weeks) in mice, the NOX4/H 2 O 2 /NFE2L2 pathway is activated, triggering a range of adaptive responses, including promoting antioxidant defense, enhancing mitochondrial biogenesis, preventing mitochondrial oxidative stress, and maintaining muscle function and exercise capacity, ultimately reducing the onset of insulin resistance associated with ageing and obesity [89]