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In addition, the duration of 10 min for heating in the boiling water bath, which was adopted from the native SIDA method, was shorter than the common duration of 30 min used in the literature [13, 14]

The treatment uses High-Intensity Focused Ultrasound (HIFU) to target the deeper layers of the skin and stimulate collagen and elastin production

The well-known geriatrician-haematologist Larry Solomon, working at Yale University in the USA, wrote 20 years ago: if I had treated only those people who actually had too low serum B12 and elevated MMA values, then I would not have treated approximately two-thirds of the people with a favourable response to B12 supplementation (note: partly via injections, partly via oral supplementation)

2020;369: m1319