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Mitochondrial Dysfunction in Familial Amyotrophic Lateral Sclerosis

10.1080/15548627.2015.1127464 139 SettembreC.De CegliR.MansuetoG.SahaP

It has been shown that, during chemotherapy, tumor cells could overcome drug-induced OS by enhancing their antioxidant systems as well as an increasing P-gp pump efflux to acquire a new redox balance due the increased ROS accumulation and antioxidant systems in a process of redox rearranging (see Figure 1)