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Although the precise mechanisms of action of Delta Sleep-Inducing Peptide (DSIP) are not fully understood, research suggests that DSIP peptide modulates multiple neurotransmitter systems, including glutamate, GABA, and serotonin

[DOI] [PubMed] [Google Scholar] 27.Diaz Vivancos P., Wolff T., Markovic J., Pallardo F.V., Foyer C.H

And sure, some of these may be due to jetlag and things the immune system hasnt been exposed to

Glutamate Toxicity Glutamate Excitotoxicity The term excitatory toxicity was first proposed in 1986 to describe the ability of excessive extracellular glutamate to kill neurons by activating NMDARs (Choi, 1988