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Further exploration of the underlying molecular mechanism revealed that Hcy-induced defects in mitochondrial homeostasis via inhibition of the Sirt1/PGC1 pathway

This belief significantly influenced the determination of the mRNA doses in these genetic vaccines, and it is an extension of the observation that survivors of severe COVID-19 exhibited a survival advantage by rapidly generating higher levels of neutralizing antibodies compared to binding (non-neutralizing) antibodies, unlike non-survivors, who produced these antibodies more slowly and at lower levels

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