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This excessive exposure to UV rays leads to a depletion of GSH, thus disturbing the redox balance

Membranes, especially those with an abundance of negatively charged lipids, are able to catalyze hiAPP transformation into an -helical structure, especially in the presence of free copper, which then leads to membrane penetration and pore formation (Sitton et al., 2025)

This adverse effect can be prevented by prior treatment with mesna (mercaptoethane sulphonic acid), which possesses both a thiol group for cytoprotection and a highly polar sulphonic acid group, and results in high renal excretion and delivery of this cytoprotective molecule to the bladder epithelium