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Importantly, there are numerous studies showing, through the regulation of the aforementioned transcription factors and more, that 4-HNE causes cell cycle arrest and inhibits the proliferation of malignant cells through the p53 and p21 dependent pathways (for review see ( Another important signalling metabolite that is generated through the cyclooxygenase-mediated peroxidation of PUFAs is malondialdehyde (MDA)

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Toxicol Appl Pharmacol 268:157177 Ndayambaje B, Amuguni H, Coffin-Schmitt J, Sibo N, Ntawubizi M, VanWormer E (2019) Pesticide application practices and knowledge among small-scale local rice growers and communities in Rwanda: a cross-sectional study