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Nonadherence rates are notably high for oral antipsychotics,Reference Garcia, Martinez-Cengotitabengoa and Lopez-Zurbano 11 with reported rates of partial or complete lack of adherence to antipsychotic medications as high as 25% within the first 1014 days after hospital discharge.Reference Velligan, Lam and Ereshefsky 12 Indeed, it is often the patients who fail to adhere to oral antipsychotic medication who are candidates for LAI treatment.Reference Kane 13 Obviously, these individuals may continue to struggle with adherence to even a short, 21-day oral aripiprazole supplementation regimen after their first AL injection

doi:10.1212/WNL.0000000000200289 Okano T, Shimomura Y, Yamane M, et al

Oxidative stressors such as 4-HNE disrupt ER homeostasis by promoting the accumulation of misfolded or unfolded proteins within the ER lumen, thereby impairing its internal environment (Ljubkovic et al., 2019

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