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Jang S, Chapa-Dubocq XR, Tyurina YY, St Croix CM, Kapralov AA, Tyurin VA, et al

Inhibition or down-regulation of GDH expression leads to a reduction in -KG production, which in turn affects the normal physiological activity of the tumour in a manner that reduces energy supply

2017;312:R5119

Meanwhile, administration of recombinant GSTA2 protein or forced overexpression of GSTA2 gene in HCC cells could contribute a compensation effect on H 2 O 2 -induced ROS elevation (ROS assay in Fig