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54 A nationwide cohort study of 120,054 patients with type 2 diabetes over a median follow up of 7.4 years found an 11% reduction in the rate of dementia with GLP-1 receptor agonists (95% of patients were on liraglutide) when used as a second-line treatment compared with other glucose-lowering therapies, with greater benefit seen with longer duration of use

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These findings are of significant importance in the real-world clinical setting, as that would mean that SIRE on OCT would manifest as hypopigmentation on CFP or ophthalmoscopic examination