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1A, KU-57788 inhibited ATC cell viability in a dose-dependent manner, with IC 50 values of 15.20 M for 8505C, 18.99 M for Hth-7, 12.62 M for CAL-62, 9.71 M for KHM-5M, and 6.95 M for KMH-2, further supporting the potent anti-tumor activity and effective DNA-PKcs inhibition of KU-57788