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2 Ferroptosis 2.1 Ferroptosis characteristics Ferroptosis causes cell membrane rupture and blistering, mitochondrial shrinkage, mitochondrial ridge decrease or removal, increased membrane density, and normal nuclear morphology, but there is no chromatin condensation, according to the ultrastructure of the cells

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Intriguingly, depletion of the H3K27me3 mark before capecitabine treatment enhanced chemotolerance, whereas simultaneous treatment with both capecitabine and a KDM6 inhibitor (to increase global levels of H3K4me3) delayed tumour recurrence 50