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Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages

[DOI] [PubMed] [Google Scholar] 25.Corrales P., Vidal-Puig A., Medina-Gmez G

Results: Based on the established therapeutic efficacy of Gastrodia elata extract against cerebral ischemia-reperfusion injury, chemical profiling identified 53 constituents, among which six were simultaneously detected in plasma and brain tissue of dosed rats

demonstrated that IAV infection induces mtROS generation, thereby causing innate immune inflammation and exacerbating viral pathogenesis in a mouse model 137