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These technologies reveal the dynamic astrocyte-neuron lactate shuttle: during learning/memory, astrocytic glycogen-derived lactate transported via MCTs promotes Arc/cAMP response element-binding protein (CREB)-dependent synaptic plasticity

This is linked to a combination of factors such as reduced intestinal motility, lower gastric acid output, and diminished BAs secretion, all of which lead to delayed clearance of intestinal contents [43, 44]

The hydrodynamic radii of fluorescent PEI-f-AuNP@Van were determined as 58 nm, which is larger than that of the bare Au-NPs (23 nm) as shown in Figure 2A

The widely accepted hypothesis proposes that motor neuron degeneration arises from the interaction between genetic susceptibility and environmental factors, primarily through mitochondrial dysfunction and cytoskeletal disruption mediated by oxidative stress and excitotoxicity (Zhou et al., 2023)