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Although the use of CT scanning has decreased this rate, a recent multi-institutional study suggests that the negative appendectomy rate (i.e., surgery is performed for presumed appendicitis, but the appendix proves to be normal) is still 6%.(7) In such cases, the surgeon traditionally removes the normal-appearing appendix because 20% to 40% will have pathological abnormalities (8) not visible to the surgeon's eyeprimarily endoappendicitis or inflammation that is confined to the mucosa or inner wall of the appendix

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Biomed Pharmacother 103:13021311 Funding This research study was the results of PhD student thesis project that was officially approved and supported by Iran University of Medical Sciences, Tehran, Iran (Grant no