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In addition to its direct antimycobacterial activity, BA promotes bacterial clearance during mycobacterial infection through the activation of the NRF2KEAP1 and HO-1 signaling pathways ( Figure 3 )

Acknowledgements SKM gratefully acknowledges the Indian Institute of Technology, Bombay, for providing JRF and SRF fellowships

Seek medical advice if you are taking B12 supplements and experience: Persistent skin changes, particularly acne-like eruptions or rosacea worsening Unexplained headaches or dizziness that coincide with supplement use Gastrointestinal symptoms including nausea or abdominal discomfort Any allergic reactions such as rash or itching Call 999 or go to A&E immediately if you experience: Difficulty breathing Swelling of the face, lips, tongue or throat Severe rash or itching Other symptoms of severe allergic reaction after taking B12 These symptoms warrant review of your supplementation regimen