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The clinical utility of nucleotide synthesis inhibitors, the first antineoplastic agents discovered, has been demonstrated in many cancers [18]

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The researchers propose that Erebosis may serve as a unique cell death mechanism that facilitates the continuous renewal of intestinal tissues while maintaining tissue integrity and avoiding immune responses ( 2.19 PANoptosis PANoptosis, a tri-modal cell death program integrating pyroptosis, apoptosis, and necroptosis, was first conceptualized by Kanneganti et al., in 2019 based on inflammasome studies during influenza infection (Shi et al., 2023)

Astrocytes exhibit significant morphological, molecular, and functional changes in response to CNS pathologies such as neurotrauma, stroke, brain hemorrhage, infections, epilepsy, and AD (Escartin et al., 2021)