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FSP1, known as a member of the apoptosis-inducing factor (AIF) family, is a key component of a non-mitochondrial coenzyme Q (CoQ) antioxidant system in the cytomembrane reported to counter lethal peroxidation and ferroptosis independently of the canonical glutathione-based system Xc /GPX4 axis (Bersuker et al

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In the past decade, significant breakthroughs have been made in comprehending the features and regulatory mechanisms of ferroptosis, and it has been confirmed that ferroptosis plays a pivotal role in the pathophysiological processes of various diseases, including tumors, inflammation, neurodegenerative diseases, and infectious diseases