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In mouse colitis models, engaging Siglec-F (such as with a Siglec-F antibody) leads to eosinophil apoptosis and has been shown to reduce colonic eosinophil numbers, although the impact on inflammation severity varied by model (some acute colitis models didn't improve, whereas chronic models or asthma models clearly benefited from eosinophil suppression) (205208)

Another strength was that this was the first study to assess the changes of oxidative stress, GSH status, and its dependent antioxidant capacities before and after hepatocellular tumor resection

Montgomery Jr., J

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