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The LEV+VPA regimen also demonstrated some degree of risk, though this did not reach statistical significance (OR = 1.17, 95% CI [0.93, 1.45], P = 0.181) (see Figure 3B)

In clinical trials of bipolar androgen therapy (BAT), metastatic CRPC patients continuously are maintained on ADT via luteinizing hormone-releasing hormone-agonist therapy and given intermittent cycles of pharmacologic SAL via intramuscular injection