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Distinct ATF1 isoforms differ in DNA-binding affinity and subnuclear localization (243), whereas multiple ATF2 variants, including the human isoforms ATF2-sm and ATF2 (SV5) as well as the murine variant Atf2(8,9) (244-246), exhibit reduced transcriptional activity and may alter gene expression by modifying nuclear-cytoplasmic trafficking or by interfering with canonical ATF2/AP-1 dimerization

Glutamine deficiency promotes PCV2 infection through induction of autophagy via activation of ROS-mediated JAK2/STAT3 signaling pathway

doi: 10.1158/2159-8290.CD-23-0299

For instance, in neuronal cells exposed to PDrelated stressors (like rotenone or synuclein aggregates), polyphenols prevent cell death: resveratrol reduces apoptosis of PC12 dopaminergic cells by upregulating HO 1 and other antioxidant defenses [39, 62]