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In doxorubicin-resistant liver cancer (BEL-7402/ADM) cells, apigenin restores drug sensitivity by reducing nuclear factor erythroid 2-related factor 2 (NRF2) expression at both RNA and protein levels through PI3K/AKT pathway inhibition, thereby increasing intracellular doxorubicin [58, 59]

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[8] References [edit] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148834 Ensembl, May 2017 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025068 Ensembl, May 2017 "Human PubMed Reference:"