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Learn about the main applications such as: Compare leads to identify the most stable lead candidates compare different anitbodies against specific targets compare variants of the same construct test variants of the same construct in the presence of competition from endogenous proteins Predict the clinical half-life of antibody-based therapeutics Allometric scaling Read the Guide Figure 1a Figure 1b Figure 1c Figure 1: Plasma concentration time plot of a) Belatacept, b) Ipilimumab and c) Pembrolizumab at single intravenous dose at 10mg/kg in Tg32 Hom (014565), mFcRn KO mice and C57BL/6J mice (000664) Figure 2a Figure 2b Figure 2c Figure 2: a) Half life curve of Belatacept, Ipilimumab and Pembrolizumab in Tg32 Hom mice (014565) correlates well to the corresponding NHP and human half life's of these antibodies

Kawahara N, Croll SD, Wiegand SJ, Klatzo I (1997) Cortical spreading depression induces long-term alterations of BDNF levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance

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