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Similarly, depletion of acetate-producing bacteria following antibiotic treatment with vancomycin reduced hippocampal levels of synaptophysin, a marker of plasticity implicated in cognition [64], and induced learning and memory deficits in a mouse model of diabetes [65]

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However, developmental changes in neurotransmitter activity are likely to result from a complex interplay between genetic and environmental factors including activity-dependent increases in synaptic strength and neuroplastic changes during adolescence

n = 446), indicating a direct association between MEIS1 binding and accessible chromatin