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Pathophysiological studies have demonstrated that elevated plasma lipid levels facilitate the infiltration and deposition of lipids within the arterial intima, subsequently triggering smooth muscle cell proliferation and foam cell formationthe hallmark cellular events in atherogenesis (Figure 1, show that the complicated pathophysiology of AS involves numerous connected pathways, including oxidative stress, lipid accumulation, inflammatory response, and endothelial injury ( Figure 1 Natural organosulfur compounds (OSCs), a class of bioactive molecules with both hydrophilic and lipophilic properties, are predominantly distributed in plant species belonging to the Cruciferae and Liliaceae families ( Freeze-dried preparations of wild garlic (Allium ursinum) cloves have been shown to contain a diverse array of OSCs, with alliin being the predominant form stored in the cytoplasmic compartment of intact cells

It is a phenomenon by which the same gene is cloned multiple times owing to the selective biosynthesis of particular codons of the chromosome [11, 28, 92]

A mechanistic study showed that reductions in the function of the intestinal barrier promote the adhesion and colonization of Enterococcus , which triggers inflammatory signaling through cell wall-associated components, such as lipoteichoic acid (LTA), which are recognized by pattern recognition receptors, including TLRs, and subsequently activates NF-B-dependent inflammatory pathways 131

doi: 10.1016/S0140-6736(25)00721-4