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Zhao J, Zhao Z, Ying P, Zhou Y, Xu Z, Wang H, et al

Elabela/toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension

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People with documented CHD and those with heart failure without preserved left ventricular function are advised to consume approximately 1 g/day of EPA + DHA preferably from oily fish, or to consider EPA + DHA supplements in consultation with a physician (104, 107)