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It is found in practically every compartment of plant cells, including the chloroplasts, apoplast, mitochondria, cytosol, vacuole, peroxisomes, and endoplasmic reticulum, and predominantly in mitochondria in animal cells [18,24]

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To further delineate the molecular basis of Ire1 inhibition in alleviating IRI, we confirmed that IRI did not significantly induce apoptosis and autophagy markers, consisting of cleaved caspase 3 and processing of LC3B, respectively, in mouse kidney (Supplementary Fig

Keeping an eye on how treatment works and making changes is critical to avoid problems