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doi: 10.3390/antiox13030298 239 KhanHA

Lactate Metabolism, Signaling, and function in brain Development, synaptic Plasticity, Angiogenesis, and neurodegenerative diseases

Since, both human (153, 155) and murine (163, 164) LN metastases can seed distant metastases, the abundance of heterogeneous cancer cell subclones in LNs could potentially give rise to more treatment-resistant cancer cells, such as the ferroptosis-resistant clones ( In the early stage of cancer progression, the sentinel LNs likely retain anti-cancer immunity to prevent cancer cell intravasation and metastasis through blood circulation