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The selection of the ligand may be designed according to the structure of the target protein as well

These strategies aim to break through the core contradiction of ferroptosis therapyhow to induce immunosuppressive M2 macrophage ferroptosis while avoiding tissue damage caused by excessive activation of pro-inflammatory M1 typeand provide a new paradigm for solid tumor immunotherapy

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However, unlike other members of the family, TGM2 is ubiquitously expressed and is secreted into the extracellular space (Chou et al., 2011