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J Biol Chem 286(29):2577825789 Haynes V, Connor T, Tchernof A, Vidal H, Dubois S (2013) Metallothionein 2a gene expression is increased in subcutaneous adipose tissue of type 2 diabetic patients

LourenCo, D., Sampaio, M

FIGURE 1 As a free radical, NO could also react with various intracellular/extracellular targets and form a series of molecules, such as NO radicals (NO - ), nitrosonium ions (NO + ), peroxynitrite (ONOO - ), S -nitrosothiols (SNOs), higher oxides of nitrogen (NO x ) and dinitrosyl-iron complexes among others, collectively these NO derivatives are termed reactive nitrogen species (RNS

Conclusions and Future Directions Curcumin holds considerable therapeutic promise in the management of CKD due to its multifaceted biological activities, including anti-inflammatory, antioxidant, and anti-fibrotic effects