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Figure 3Da depicts the pseudotime trajectory of progenitor cells, with branches corresponding to differentiated cell types integral to cartilage and epithelial regeneration

On microglial cells, the mechanism of AMPK activation through ROS and calcium signaling pathways during P2X7R stimulation, leading to mitochondrial division, induction of mitophagy, and activation of the nuclear transcription factor TFEB has been proven (Sekar et al., 2018)

Characterization of microbial communities from gut microbiota of hypercholesterolemic and control subjects