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The only conclusions that can be drawn by reviewing the existing literature at this point seem to be 1: The bending rigidity of red blood cells is reported over a large range, from 3 k B T to about 100 k B T, which does not depend on the technique 2: The spread in values cannot be explained by a length scale dependence of , as techniques which measure on large length scales report small and large values and vice versa 3: Techniques that isolate the RBC cytoplasmic membrane and only measure of the RBC cm report very small values, between 46 k B T 4: Because of these measurements, the contribution of the spectrin network is likely negligible as there are measurements of entire RBCs which also report such small values

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& Gundelfinger, E