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Braaks hypothesis suggests that the -synuclein pathology begins in the ENS and then migrates to the brain, passing through the brainstem, midbrain, basal forebrain, and finally the cortical areas [118, 119]

If other anti-inflammatory drugs (e.g., biologics, immunosuppressants) have similar effects is currently not known

In photothermally induced drug delivery, nanocarriers go under light-heat transformation when they are exposed to an optical trigger and the obtained increasing local temperature would lead to drug release

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