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* Correspondence: Yan Lu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Finally, regarding interventions, clinical trials are frequently plagued by high heterogeneity, small sample sizes, short durations, and a lack of standardized adverse event reporting, resulting in a low certainty of evidence for most therapies and an inability to guide personalized care

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